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Surface plasmon fluorescence s pectroscopy (SPFS) [1-3] and surface
plasmon diffraction spectroscopy (SPDS) [4-6] are two recently
developed high performance sensing techniques. For SPFS, the surface
plasmon field enhancement in combination with a three-dimensionally
extended surface function matrix (CM5, Biacore) ensures an atto-molar
(10-18 M) sensitivity in detecting fluorescently labelled
antibodies. [1] In a complementary way, SPDS offers label-free
sensing with highly improved performance in comparison with the
conventional surface plasmon resonance spectroscopy (SPR). The
promising future of both techniques is strongly demonstrated by
abundant examples in DNA assay, (clinical) immunoassay and
nano¬particle analysis.R
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Presented at the International Congress
of Nanotechnology, November 7-10, 2004 San Francisco, USA
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