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Unimag For Treating Of Pyo-Septic Processes Besik Surguladze, Tamara Tskitishvili, Artem Bagishvili Centre of clinical medicine, Tbilisi, Georgia 6/10 Baratashvili Str. Tbilisi, 0105, Georgia, E-mail: ATT.BVS@ti.net.ge In spite of numerous methods and remedies, treatment of pyo-septic processes remains problematic, that calls for an urgency of research of new effective remedies in this direction. Offered by us “Unimag” represents stable suspension of high disperse magnetite (HDM) on water bases. HDM particles are spherical form, 10-15 nanometers in size, X-Ray contrast and magnet-sensitive. Experimental investigations of medico-biological characteristics show that HDM is characterized by bactericidal and bacteriostatic activity, with a remarkable ability to adsorb and neutralize toxic components as an antibacterial of metabolic origin. HDM can be shown to , increase proliferating activity of mononuclear and phagocitic activity of eliminated cells, as well as stimulate the production of Interleukin -1 and other factors of grow by macrophages. Analysis of clinical materials showed high affectivity of “Unimag” in the complex of treating and prophylactics of pyo-septic processes. The study of the mechanism of action suggests that that HDM actively takes part in the process of fighting aggressive factors, compensating some broken functions of detoxification system of organism. The main question in this direction is the decision of the problem of local inflamed processes, as the main source of the toxic components. Morphological investigations showed, that HDM particles adsorbs on the surface of tissue at the lesion places, where they could function as open doors for the penetration of aggressive factors. Located at this place HDM particles hinder the penetration of infection in the depth of tissue. It has been demonstrated that being adsorbed at the sites of lesion HDM particles gradually move in the depth of tissue, adsorbing on erythrocytes and phagocyted by neutrophils and penetrating in bloodstream. Phagocyted by macrophages HDM particles move to lymphatic capillaries and consequently lymphatic nods. HDM leaves the organism in the liver in unchanged form. Besides of medico-biological characteristics described above, the “Unimag” can easily be prepared in water soluble solutions. Because of large surface area due to high disperse size of magnetite particles, HDM solution can easily penetrate into tissues together, and has demonstrated successful application in treating various etiology and localized inflamed processes of soft and bone tissues.
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Presented at the International Congress
of Nanotechnology, November 7-10, 2004 San Francisco, USA
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