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Fabio
Pichierri Sizeable quantum effects in a specific biological signal transduction event have been recently discovered. Linear-scaling quantum mechanical calculations performed on the complex between the SH2 domain of a protein tyrosine kinase and a phospho-peptide indicate that upon binding the macrodipole of the protein is rotated by ~150 degrees from its initial orientation. This interesting finding suggests about the possibility of employing the SH2 domain as a molecular switch for 21st century nanoelectronics. Furthermore, additional aspects concerning both signal integration and signal amplification in biological systems are also discussed.
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Presented at the International Congress
of Nanotechnology, November 7-10, 2004 San Francisco, USA
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